Research Projects

Precise regulation of transcription is central to cellular homeostasis and an organism’s response to developmental, nutritional, and environmental signals. Transcription factors bind to DNA to directly regulate gene expression and control cell fate. We develop and adopt molecular genomics approaches to study regulatory cascades initiated by hormone signaling. The lab’s current work focuses on the basic mechanisms of estrogen signaling in breast cancer and how signaling cascades are disrupted upon tamoxifen treatment. We also use integrative genomics approaches to study glucocorticoid-induced apoptosis in glucocorticoid-sensitive and resistant acute lymphocytic leukemia cells. A long-term goal of the lab is to identify transcription factors that are responsible for hormone-resistant phenotypes in cancer cells.